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Faculty Research Interests


Tobacco Cessation

Claudia Barone, EdD, RN, LNC, CPC, CCNS-BC, APN

My research program involves tobacco cessation. The first area of interest is in training health care providers in the delivery of evidence-based tobacco cessation strategies to patients. This research includes education of health care providers on brief motivational interviewing, counseling, cessation strategies and pharmacotherapy for cessation through pre tests, post tests and 6-month follow-up surveys assessing knowledge and self-efficacy.

A second research focus revolves around establishment and data collection of patients seen in a tobacco cessation clinic. These patients will be assessed using an evidence-based tobacco cessation questionnaire and from the results, develop an individualized, evidence-based tobacco cessation plan. This research is interdisciplinary involving the Colleges of Health Professions and Medicine and the clinic is location in the UAMS Winthrop P. Rockefeller Cancer Institute.

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Geriatrics and Integrated Community-Based
Systems of Healthcare and Social Service Delivery

Claudia Beverly, PhD, RN, FAAN

My areas of research interests include geriatrics and integrated community-based systems of healthcare and social service delivery.  My goal is to develop systems of care delivery for older adults that places them in the least restrictive environment and to link the care needed to the right health care provider that is the most cost effective.  My secondary area of research interest is long-term-care with a particular focus on tele-health.

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Depression in African-American Males; Community Based
Participating Research

Keneshia Bryant, Phd FNP-BC

My primary goal is to develop a program of research that will improve understanding of the experience of depression among African American males in order to provide timely recognition and intervention through faith-based community programs. In addition, through my research I plan to gain a better understanding of how ethnicity and culture impact depression.  Collaborations between community organizations, the faith community, and healthcare professionals will aid in the achievement of my goals.

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Comparison of Virtual Reality and Passive Distraction
on Burn Wound Care Pain in Adolescents

Dona Dorman, MNSc, RN, RNP

While working at the Burn Center at ACH, I became interested in nurses’ concerns with patient procedural pain, and was excited to work with the principal investigator, Dr. Debra Jeffs, as she began research on this topic. Wound care following burn injuries often inflicts severe pain requiring pharmacologic and non-pharmacologic interventions, such as distraction. The purpose of the study is to compare the effectiveness of virtual reality (VR) with passive distraction (PD) and standard care (SD) on burn wound care pain in adolescents. Less anxiety, greater desire to use distraction and belief in its efficacy, and greater engagement with distraction are hypothesized to increase effectiveness of the distraction and lessen pain during wound care. The study builds on and extends evidence supporting virtual reality as an engaging, effective distraction for adolescents during burn wound care and provides pilot data for future research testing the effectiveness of tailoring non-pharmacologic interventions to reduce procedural pain.

[Comparison of Virtual Reality and Passive Distraction on Burn Wound Care Pain in Adolescents Jeffs D, Dorman D, Brown S, Files A, Goforth E, Graves T, Killebrew P, Kirk E, Meredith-Neve S, Sanders J, White B, Braden E, Hill T, Swearingen C.]
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Sleep Disruption and Other Symptoms Associated with Cancer

Carol Enderlin, PhD, RN

My research focus is sleep in older adults with cancer, as well as the interrelationship of sleep with other symptoms commonly experienced including mood changes, fatigue and pain. I am interested in non-pharmacologic interventions for management of insomnia, as an alternative or to complement traditional pharmacologic therapy, such as sleep medication. Currently I am conducting a pilot feasibility study of a standardized guided imagery intervention compared to a sleep-hygiene education intervention for the relief of insomnia symptoms in women over 55 years of age with non-metastatic breast cancer.

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Depressive Symptoms and Genetic Influences on Cardiac Outcomes

Lorraine Frazier, PhD, RN, FAHA, FAAN, Dean and Professor

My NIH funded R01, “Depressive Symptoms and Genetic Influences on Cardiac Outcomes,” focuses on the interactions of behavior and genetics on patients who are diagnosed with acute coronary syndrome.

Patients with acute coronary syndromes (ACS) who screen positive for depression are at greater risk for subsequent major adverse coronary events (MACE). Depressive symptoms are associated with increased inflammatory protein levels, but only in certain individuals. In a prospective study of ACS patients, my research is designed to test a biobehavioral model in which inflammatory protein gene polymorphisms interact with depression resulting in even greater increases in inflammatory protein levels than those caused by either gene polymorphisms or depression alone. We expect to identify a well-defined, high-risk subgroup of ACS patients in whom the interaction of depression and the genetic polymorphisms identified increases risk of subsequent MACE (myocardial infarctions, revascularization procedures, strokes, and death)more than does either of these factors alone, in part because of their combined effect of increasing inflammatory proteins.   We are measuring the following Inflammatory proteins and genes: Interleukin (IL) 6, C-reactive Protein (CRP), Tumor Necrosis Factor Alpha (TNFα), E-Selectin (SELE), and Monocyte Chemoattractant Protein-1 (MCP-1).To test these hypotheses, we have enrolled 1200 ACS patients from two large tertiary care centers and obtained blood samples for measurement of inflammatory proteins and genetic testing as soon as possible after hospital admission. Patients were screened for depression using Beck Depression Inventory (BDI) II scores. Demographic and clinical risk factors will be assessed. We are in the process of completing collection on two years of annual follow-up for MACE.

The discovery of a relationship among depression, genetics, inflammatory protein levels, and subsequent MACE in an ACS subgroup would provide a rationale for studying environmental triggers of depression and the effects of depression interventions (different medications, psychotherapies, combinations of treatment, and self-management techniques such as exercise) on inflammatory protein levels for their effects on future MACE. The ability to decrease mortality and morbidity in ACS patients would benefit public health efforts, particularly efforts to improve the health of older persons, who are more prone to coronary events.

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Quality of Life and Psychosocial Outcomes in Pediatric Heart Disease -
Implementation of Evidence-Based Practice

Angela Green, PhD, RN, NNP-BC, APN

My research focuses on two areas: a) quality of life and psychosocial outcomes in pediatric heart disease and b) implementation of evidence-based practice. My team has completed two qualitative studies examining the quality of life of children and adolescents who have undergone heart transplantation. We are currently seeking funding for a study that focuses on adolescents’ transition to self-management after transplantation.  In our evidence-based practice work, we are conducting an Arkansas Children’s Hospital Research Institute/Arkansas Biosciences Institute funded intervention study designed to develop clinical area based mentors for evidence-based practice change.

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Congestive Heart Failure, Quality of Life, Symptom Management

Seongkum Heo, PhD, RN

My recent research interest areas are quality of life, self-care, and symptoms in patients with heart failure. I have examined factors affecting self-care, symptoms, and quality of life, and the relationships among the factors. I have conducted studies examining the effects of modifiable factors including psycho-social and behavioral factors on symptoms, quality of life, and hospitalizations and mortality. Psychosocial factors include depression, perceived control, and social support. Behavioral factors include medication adherence, dietary adherence, and symptom management. I have been involved in development and delivery of dietary interventions to help patients with heart failure or kidney diseases managing diet effectively.

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Psychological and Psychosocial Effects on Trauma

Sara Jones, PhD, RN

I am interested in the psychological and psychosocial effects on individuals who experience trauma, as well as perpetrate violence. My research has focused on assessment and treatment of individuals convicted of a sexual offense, including adult males and females, along with adolescent males. I have also focused on the lives of parents of adolescents who have sexually offended and the resources they need to cope with the experience. Currently, I am expanding this area of interest by using neuroimaging to evaluate the brain’s response to trauma in adolescent victims as well as perpetrators.

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Heart Disease Prevention & Physical Activity Interventions for Older Adults

Leanne Lefler, PhD, Adult/Gerontology Clinical Nurse Specialist-BC, APRN

Coronary heart disease (CHD) is the major killer in the United States, affecting over 17 million with a cost estimated at $2 billion annually. Of all diagnoses, spending for CHD is predicted to escalate as the baby boomers retire. My research focuses on the prevention and early treatment of CHD in older adults. I have examined the accuracy of older, racially diverse women’s perception of their personal risk for heart disease, understanding of cardiac risk factors, and the factors that promoted or hindered their attempts at modifying cardiac risk factors. With an interdisciplinary team, I also examined medication adherence in older women with CHD and described typographies of veterans with heart failure concerning values and needs at end of life.
I have conducted quantitative, qualitative, and mixed-method research and worked in the church community, acute care and primary care environments. Currently, my interdisciplinary research team is conducting an NIH-funded randomized controlled trial aimed to promote physical activity in older, community dwelling women. We are also involved in feasibility work to determine best methods of conducting research involving physical activity interventions in older adults. I remain very interested in improving the health and well-being of older adults and have published widely on these topics. I also lead the education mission of the College’s Hartford Center of Geriatric Nursing Excellence, a center dedicated to improving the health of older adults and their caregivers, and improving the capacity of nurses to teach and care for older adults.

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Women and Heart Disease; Psychiatric Disorders and Stress in Veterans:
Risk Factor Modification

Jean McSweeney, PhD, RN, FAHA, FAAN

Women continue to have difficulty receiving early diagnoses of coronary heart disease (CHD) and tend to have advanced CHD when diagnosed. I have been investigating women’s early warning and acute symptoms associated with CHD in order to promote early recognition of CHD symptoms.  We have recently completed two grants, one funded by the National Institute of Nursing Research, and one by the UAMS Translational Research Institute. These grants focus on predicting which women will have a CHD event in the next two years based on their symptoms, risk factors, and biomarkers. We use an instrument in these studies that we have developed and refined with previous research funded by the National Institute of Nursing Research. Our goal is to further refine this instrument and include the most predictive symptoms and biomarkers based on these 2 studies. Our next proposal will test the predictive ability of our revised instrument in a diverse sample of women. I have also conducted research in other areas of cardiac research including cardiac rehabilitation, heart transplantation, and heart failure.  I also have appointments with the Veterans’ Administration and the College of Public Health and serve as a co-investigator on a variety of grants. These studies focus on veterans with posttraumatic stress syndrome, families of returning veterans, rural health access, obesity, and food selection and availability. I am very interested in tailoring bio-behavioral interventions. I am also involved in the UAMS Translational Reserve Institute.  I use both qualitative and quantitative methods in my research endeavors.

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Neonatal Pain and Stress Management

Anita Mitchell, PhD, RN, FNP-BC, APN

My research focuses on preterm infants and infants with congenital defects or who are ill and may undergo multiple painful procedures daily. The pain of these procedures as well as the stress of being in a neonatal intensive care unit (NICU) may result in adverse physiological and neuro-developmental consequences. Clinical research lays the foundation for evidence-based practice to prevent and relieve pain and stress in neonates. We are engaged in research to test the effectiveness of alternative forms of pain and stress management such as kangaroo care, massage therapy, administration of 24% sucrose, and gentle, low current electrical stimulation. We are also studying the physiologic effects of routine procedures such as eye exams for retinopathy of prematurity.

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Multimodal e-Learning Strategies for Evidence Based practice in Education and Practice

Barbara Pate, PhD, RN, Clinical Assistant Professor

Evidence Based Practice (EBP) is widely acknowledged as an effective approach to delivering health education and care that is grounded in quality research, clinical wisdom, and patient preferences. EBP requires that nurse educators and practitioners critically evaluate the rationale and effectiveness of the content and care provided. To accomplish this high level of scrutiny, healthcare systems must have access to knowledge resources that provide the foundation for guiding and improving practice. However, a lack of resources in terms of capacity for training and skills development is a major obstacle that nurse educators and practitioners face when building and sustaining EBP. The use of multimodal e-Learning technologies has the potential to build the knowledge, skills, and abilities for EBP in a multispatial environment that is not constrained by time or geographical barriers. Current research projects include 1) an experimental study to test the effectiveness of a researcher-developed Website for EBP training for staff nurses located in a rural setting, 2) an interventional study examining e-Learning for building EBP capacity, and 3) a meta synthesis on effective e-Learning strategies for online education.

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Cardiovascular Disease; Health Disparities

Christina Pettey, PhD, FNP-BC, APRN

Cardiovascular disease (CVD) is the leading cause of death world-wide and African Americans are disproportionately affected by it. My research has focused on eliminating the disparity in CVD outcomes for African Americans. I recently completed my dissertation study and NIH-funded NRSA titled: “Factors affecting hypertension treatment adherence among African Americans” (No. 1-F31-NR012347). Participants in this study attempted to adhere to medications and lifestyle changes to lower their blood pressure but lacked the knowledge to do so effectively. My next study will explore ways to improve the cardiovascular health of African Americans using education and lifestyle interventions. I have been a volunteer family nurse practitioner in a free, faith-based, primary care clinic and my interest in health care disparities has grown out of my clinical experience in providing care to the uninsured, indigent residents of central Arkansas

 

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Nursing Student Preparedness for Disasters

Cheryl K Schmidt, PhD, RN, CNE, ANEF, FAAN

Since 2006, I have been studying nursing students’ preparedness for disasters. I conducted a national survey of students through the National Student Nurses’ Association, and learned that nursing students were not prepared. I began teaching our students to respond to disasters through the American Red Cross, then led a national team to develop a course through the American Red Cross that is being taught in nursing programs throughout the United States. We are now surveying those who complete the course to determine whether they become involved in the Red Cross.

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Arthritic Pain; Tai Chi in Elders; Dementia

Pao-Feng Tsai, PhD, RN

Alice An-Loh Sun Endowed Professorship in Geriatric Nursing

Many persons with dementia suffer from chronic pain that may exacerbate existing cognitive impairment and lead to further suffering. Inability to communicate pain poses great difficulty for pain management in persons with dementia; consequently, their pain tends to be under-treated. Since pain management depends on adequate assessment, it is necessary to find a valid tool to assess pain in this vulnerable elderly population.  Therefore, my first NIH funded project, was to study pain behaviors as an objective measure of osteoarthritic knee and/or hip pain. The long term goal of this project was to develop an assessment model that predicts osteoarthritic knee and/or hip pain in elders with severe dementia. My second NIH funded project was to study the effect of Tai Chi, an ancient Chinese martial art, on osteoarthritic knee pain in elders with mild dementia. Many elders show symptoms of osteoarthritic knee while they reside in the community and still actively engage in many social functions. Pharmacological interventions have limited effects and produce serious side effects. Therefore, it is important to identify an effective non-pharmacological intervention to reduce their osteoarthritic knee pain. Our findings showed that Tai Chi is effective in reducing knee pain in this population. My future research will focus on comparing the effectiveness of Tai Chi and other exercise for reducing knee pain in this population.

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Ethical, Legal and Social Issues (ELSI) of Personalized Medicine

Pamela Holtzclaw Williams JD, PhD, RN

My research interest focuses in ethical, legal and social issues (ELSI) of personalized medicine, especially the impact this healthcare agenda has on communities living with rare, genetic conditions. I apply community based participatory research partnership (CBPR) approaches in my work. I am cross trained and experienced in both quantitative and qualitative methods, and have experience in applying these methods to psychosocial measurements’ psychometric development. My funded program of research has led to work with communities living with Huntington’s disease, other rare neurogenetic conditions and most recently with the rare condition referred to as Alpha-1 antitrypsin deficiency disorder. I find my legal, nursing and research training and experience blend well together to advocate for and empower community leaders to obtain better healthcare delivery for persons living with rare genetic disorders.  Specific categories of ELSI issues that hold my current interest are: 1) the clinical utility of pharmacogenomics,2) biobanking patient samples for future personalized medicine research, and 3) measuring  constructs such as social burden and capacity for patient centered outcomes research in individual rare disease communities.

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HIV/AIDS, Substance Abuse, and Mental Health

Patricia Wright,  PhD, MPH, RN

My research focuses on HIV prevention, drug use, and mental health. There are wide disparities in HIV and AIDS rates among African Americans and Whites, especially in the South. Drug use has been recognized as one of the driving forces in spread of the epidemic as well as a major barrier to service utilization. I have used qualitative and quantitative methods to examine individual, structural, and contextual barriers and facilitators to HIV testing among rural African American cocaine users, and to integrating HIV testing in substance abuse treatment and other community locations from the perspectives of drug users and providers. Such knowledge is especially needed in the rural South, where the HIV epidemic is growing rapidly. One of the major findings from this study is that many rural African American cocaine users assume they have been tested for HIV as part of routine care. We do not know at this time, however, if this passive testing phenomenon is prevalent beyond this sample of rural African American drug users, perhaps extending to urban drug users or the general population.  Future research will investigate the extent of passive testing assumptions in this high-risk population and among others, as well as examining racial/ethnic, gender, and generational differences in risk behaviors, risk perception, and HIV testing.  I also collaborate with investigators from the College of Public Health where I serve as project director and co-investigator for a clinical behavioral trial of a sexual risk reduction intervention among rural African American cocaine users. I am very interested in access to health services and factors that influence use of health services.

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